SubtiHance® (Gadoteridol)
SubtiHance® is the trusted macrocyclic gadolinium-based Non Ionic 0.5 M, MRI contrast agent designed for precision in diagnostic imaging. For over 30 years, it has remained a daily choice for MRI professionals in more than 40 countries, with 40 million vials sold, providing a reliable solution for high-quality contrast-enhanced MRI.
Overview
As a premium non-ionic macrocyclic GBCA, SubtiHance is defined by its exceptional physicochemical properties that facilitate high-performance MRI. The macrocyclic structure provides high thermodynamic and kinetic stability, effectively minimizing the risk of gadolinium ion release within the body. This stability is paired with low viscosity and low osmolarity, allowing for a more compact bolus during injection. These technical specifications are particularly beneficial in specialized imaging techniques like perfusion MRI, where high flow rates - up to 6 ml/s - are required to accurately map brain biomarkers and vascular structures without compromising patient comfort or safety.
Key Features
- Superior Macrocyclic Stability: Engineered with a macrocyclic structure that ensures high thermodynamic and kinetic stability, minimizing the release of free gadolinium.
- Proven Safety Profile: Documented in prospective studies of over 20,000 patients, showing an exceptionally low adverse drug reaction (ADR) rate of 0.16%.
- Optimized Fluid Dynamics: Features low viscosity and low osmolarity, enabling high-flow injections (up to 6 ml/s) for a tighter bolus and sharper image definition.
- Minimal Tissue Retention: Clinical and animal studies demonstrate minimal residual gadolinium levels in brain tissues compared to linear and other macrocyclic agents.
- Approved- US FDA, EU . Available as Prohance globally.
Clinical Applications
- CNS MRI (Adult & Pediatric): Indicated for detection of lesions in the brain and spine, providing diagnostic information superior to unenhanced MRI in patients 2 years and older.
- Liver Imaging: Specifically approved for detecting focal liver lesions, such as hepatocellular carcinoma or metastatic disease, providing strong arterial phase enhancement. Also for Delayed imaging up to 3 hours, as Multihance is retained by the hepatocytes.
- Central Nervous System (CNS) Imaging: Enhances MRI of the brain and spine for superior detection and characterization of tumors, inflammatory diseases, and vascular lesions.
- Perfusion-Weighted Imaging: Utilized for quantitative assessment of cerebral blood flow and volume, critical for oncology and stroke management.
- High-Resolution Diagnostic Support: Provides the high sensitivity and specificity required to confirm diagnoses against histopathology standards.
- Pediatric and Adult Radiology: A trusted choice for a wide patient demographic due to its long-term clinical experience and established safety data.
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Multihance
MultiHance® is a multipurpose, high-relaxivity magnetic resonance imaging (MRI) contrast agent designed to provide superior diagnostic clarity across a wide range of clinical applications. As a high-performance GBCA, it is distinguished by a longitudinal relaxivity (r1) that is approximately double that of standard gadolinium chelates. This enhanced signal strength allows for better lesion depiction and improved diagnostic accuracy in both adult and pediatric patients (age 2+ for CNS), making it a cornerstone for complex imaging needs.
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