Multihance
MultiHance® is a multipurpose, high-relaxivity magnetic resonance imaging (MRI) contrast agent designed to provide superior diagnostic clarity across a wide range of clinical applications. As a high-performance GBCA, it is distinguished by a longitudinal relaxivity (r1) that is approximately double that of standard gadolinium chelates. This enhanced signal strength allows for better lesion depiction and improved diagnostic accuracy in both adult and pediatric patients (age 2+ for CNS), making it a cornerstone for complex imaging needs.
Overview
The technical advantage of MultiHance lies in its high-relaxivity profile, which remains superior at all clinically relevant field strengths up to 3T. Its unique formulation allows for dual-route excretion, with approximately 2–4% being eliminated via the hepatobiliary route, which facilitates specialized liver imaging in addition to standard CNS and vascular assessments. MultiHance maintains a robust safety profile; post-marketing surveillance of over 17.5 million patients shows an adverse event rate below 0.05%, with most reactions being mild and self-resolving.
Key Features
- Superior Longitudinal Relaxivity (r1): Delivers higher signal intensity (r1 of 6.7 in blood at 1.5T) compared to standard agents like Dotarem® or Magnevist®,or Omniscan resulting in better contrast-to-noise ratios.
- Enhanced Lesion Visualization: Significantly improved qualitative and quantitative brain lesion depiction confirmed in randomized, double-blind crossover trials.
- Validated Safety Record: Established tolerability in children, elderly patients, and those with renal or hepatic impairment, with no unconfounded cases of NSF. Multihance is not contraindicated in Renally impaired patients up to GFR>30 ML.
- Efficient Dosing: High relaxivity allows a standard 0.1 mmol/kg dose to provide diagnostic performance equivalent to double doses of standard agents in specific vascular studies.
- Only Hepatobiliary excretory MRI agent, in addition to Renal clearance in India. Excellent in Liver, Biliary tree imaging.≈MRI agent, in addition to Renal clearance in India. Excellent in Liver, Biliary tree imaging.
Approved by US FDA, EU .
Clinical Applications
- CNS MRI (Adult & Pediatric): Indicated for detection of lesions in the brain and spine, providing diagnostic information superior to unenhanced MRI in patients 2 years and older.
- Liver Imaging: Specifically approved for detecting focal liver lesions, such as hepatocellular carcinoma or metastatic disease, providing strong arterial phase enhancement. Also for Delayed imaging up to 3 hours, as Multihance is retained by the hepatocytes.
- Breast MRI: Offers superior efficacy in malignant lesion detection and differentiation compared to standard gadolinium chelates.
- Magnetic Resonance Angiography (MRA): Improves diagnostic accuracy in detecting steno-occlusive vascular disease in abdominal and peripheral arteries.
- Cardiac MRI- CNR values with Multihance is significantly higher than any other competitor, thus increasing robustness of the diagnosis.
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