Next-generation sequencing (NGS) in Newborn screening offers a powerful, high-throughput method to detect genetic disorders early in life. Unlike traditional screening methods that test for a limited set of conditions, NGS can analyze multiple genes simultaneously, identifying a wide range of genetic mutations associated with inherited diseases. This approach allows for more comprehensive screening, early diagnosis, and personalized treatment, potentially improving outcomes for newborns. As NGS technology becomes more accessible and cost-effective, its integration into routine Newborn screening could significantly enhance the early detection and management of genetic conditions.