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05 Nov 2012

Pap Smear turns over a leaf

05 Nov 2012

One out of every four cervical cancer patients in the world are Indians medical experts feels the need for more effective diagnostic technology. Evolution of science is changing the face of earth in leaps and bounds, where yesterdays advancement is becoming obsolete. Epidemic diseases have cure today, diagnosis of life threatening diseases like Cervical cancer has progressed with the advancement of technology. Studies show that more than 90% of the women are diagnosed with cervical cancer are having Human Papillomavirus (HPV). However Pap smear is more than 60 years old and this technique is found to have limitations. This includes, more false negative rate which can then progress and when detected can cause more costly medical interventions.Thin Prep is significantly more effective than conventional Pap smear for the detection of epithelial Lesions.While HPV does not mean a woman will contract cervical cancer but it is important to be aware of HPV and its links with cervical cancer, which constitutes to infect 6.2 million each year .More than 25% are found in India. The Thin Prep test can also be used to screen for HPV. The Thin Prep system uses liquid based technology to address preparation and screening errors, which account for the majority of the Pap smear inaccuracies. Benefits of Thin prep over conventional : Decrease in sampling error  In conventional pap testing - a) Cells not collected properly , b) Cells are not transferred on slide completely , c) Cells are not preserved completely leading to drying artefacts. All these are avoided in Thin Prep Pap test thereby causing Higher cell yield  as more than 80% cells are discarded in conventional technique. Decrease in transportation errors  Slide Breakage is avoided , mislabelling is minimised. Decrease in screening errors  false negative rate is minimised. Diagnostic accuracy is far more than the conventional. Decrease in interpretative errors, Due to excellent fixation of cells , interpretation is made very easy leading to decrease in repeat pap smear testing. No ambiguous reports. Decrease in inadequacy / unsatisfactory rate. Decrease in limiting factors like blood mucous , inflammation etc. Additional testing of HPV is possible in same vial. No need to collect another sample thereby decrease patient trauma. Glandular disease detection rate is superior. However Pap smear is more than 60 years old and this technique is found to have limitations. This includes, more false negative rate which can then progress and when detected can cause more costly medical interventions.Thin Prep is significantly more effective than conventional Pap smear for the detection of epithelial Lesions.While HPV does not mean a woman will contract cervical cancer but it is important to be aware of HPV and its links with cervical cancer, which constitutes to infect 6.2 million each year .More than 25% are found in India. The Thin Prep test can also be used to screen for HPV. The Thin Prep system uses liquid based technology to address preparation and screening errors, which account for the majority of the Pap smear inaccuracies. Benefits of Thin prep over conventional : Decrease in sampling error  In conventional pap testing - a) Cells not collected properly , b) Cells are not transferred on slide completely , c) Cells are not preserved completely leading to drying artefacts. All these are avoided in Thin Prep Pap test thereby causing Higher cell yield  as more than 80% cells are discarded in conventional technique. Decrease in transportation errors  Slide Breakage is avoided , mislabelling is minimised. Decrease in screening errors  false negative rate is minimised. Diagnostic accuracy is far more than the conventional. Decrease in interpretative errors, Due to excellent fixation of cells , interpretation is made very easy leading to decrease in repeat pap smear testing. No ambiguous reports. Decrease in inadequacy / unsatisfactory rate. Decrease in limiting factors like blood mucous , inflammation etc. Additional testing of HPV is possible in same vial. No need to collect another sample thereby decrease patient trauma. Glandular disease detection rate is superior.


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